Guitar Hero: On Tour continues to build on the franchise's signature easy-to-play, yet difficult to master addictive gameplay, and now lets players take their experience on the road wherever they go. Players use the Guitar Hero pick-stylus on the touch screen to strum their favorite tunes and create their rock 'n' roll legacy in career mode.

Fans can also join together to play co-op mode using a local wireless network, or battle each other in a Guitar Duel using new Battle Items unique to the DS platform. For example, players must blow into the microphone to extinguish a pyrotechnics effects gone wrong, or use the touch screen to autograph a crazed fan's shirt in the middle of their set.

Featuring five unlockable new venues, the game lets players personalize their experience by choosing the color of their axe of choice, selecting to play as one of six characters - two of which are all new and exclusive to Guitar Hero: On Tour - and outfitting their guitarist in numerous styles.